"Interferometric lithography (IL) has been used for many years in semiconductor nanofabrication, but has been little used for molecular nanopatterning. We have found that in combination with self-assembled monolayers as resists, it provides a very simple and rapid means to fabricate nanostructured metals, oxides, polymers and biomolecules over areas as large as 1 sq. cm. An introduction to the methodology that we use in this video.