The INSIGNEO Institute for in silico medicine is a collaborative initiative between the University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust. It is a multi-disciplinary institute involving over 80 academics and clinicians who collaborate to develop computer simulations of the human body and its disease processes that can be used directly in clinical practice to improve diagnosis and treatment. This is probably the most sophisticated application of computing technology in healthcare, and Sheffield has become the UK's main centre for this work.
http://www.insigneo.org
http://www.sheffield.ac.uk