Amyloid Disease: Are the oligomeric toxic species a good target for therapeutics?

It is believed that in many amyloid diseases, including Alzheimer’s, the primary toxic species responsible for neurodegeneration are small oligomers of the causative protein, rather than the fibres that often define the disease. I have, therefore, isolated oligomers of our model protein Cystatin B and those of Amyloid β in order to further characterise them.